Active Ingredients: Isotretinoin
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This results in discontinuation of treatment or compliance problems in patients who continue treatment. Isotretinoin ITN, a derivative of retinoic acid 13-cis-retinoic acid, is the most effective compound with potential to suppress acne over the long term.
However, low solubility of ITN limits its incorporation in a suitable vehicle while its poor photostability renders the topically applied drug ineffective.
Therefore, the development of novel formulations characterized by high photoprotection of ITN seems to be important, as well an efficient investigation about the photodegradation processes occurring in the ITN in the developed formulations.
The inclusion of the drugs in the novel formulation matrix represents an approach of growing interest to the problem of light-sensitive drugs.
Also, topically applied microemulsions MEs have been demonstrated to significantly increase the cutaneous absorption of both lipophilic and hydrophilic drugs compared to conventional vehicles for example, aqueous solutions, neat oil phases, micellar solutions, emulsions, and liposomes.
Drugs photostability represents a significant problem in pharmaceutical research, several articles and reviews dealing with different aspects of such studies are present.
When the ME region extends from an oil-rich region i.
The phase study revealed that the maximum solubilization of water was achieved in ME systems when Km was 3:1 and so it was fixed at 3:1 for further studies.
The obtained results suggested that the maximum solubilization of water Wmax was increased with decrease in the amphiphile content in the ratio of oil to Emix in the order of 0.
The Wmax was achieved at a ratio of oil to Emix less than 0.
It was considered that IPM, due to its preferable chemical structure, probably penetrated the interfacial layer and interacted with LAB, increasing its efficiency in solubilizing water.
Hence, the obtained results indicated that LAB showed a good efficiency and water-solubilizing capacity in the presence of IPM. These observations were quite consistent with previously reported results Djekic and Primorac.
The unloaded vehicles have a globule size in the range of 22. Two explanations, 1 undissolved drug acting as a emulsifier and 2 reduction in emulsifier mobility, are offered in the literature for the decrease in droplet size with the addition of the drug due to deposition of drug particles at the interface of ME Biruss and Valenta; Djekic and Primorac; Fanun; Kantarci et al.
It has been reported that the lowest conductivity plots extend to the largest droplet radius.
The size of the droplet of unloaded ME with low conductivity values was greater than that of the ITTN-loaded formulation with higher conductivity values Patel et al.