Active Ingredients: Isotretinoin
Discussion about the teratogenicity and recognized side effects should be recorded in the notes at each visit, and patients should be given appropriate written information. Mood changes including depression are common among adolescents and have been reported in acne patients treated with isotretinoin.
Two studies that looked at spontaneous reports of side effects for the FDA in the USA 53, 54 found little or no increase in psychiatric disease including depression and suicide over the background prevalence in the adolescent population.
A further study of general practice databases in Canada and the UK showed similar findings as have subsequent studies.
Despite contradictory reports clinicians have been advised of a potential rare idiosyncratic reaction in some young vulnerable patients which could lead to mood changes and clinical depression during treatment with isotretinoin.
It is therefore advisable to specifically enquire about related symptoms at each clinic visit.
Increased aggression has been identified in some male patients and the FDA in the USA has advised clinicians to warn potential patients about this side effect. If there is any doubt, the drug must be stopped.
The mucocutaneous side effects are dose dependent and can usually be controlled with regular use of moisturizers and lip salves.Open in a separate window 1. Patients in Group 2 are those.
Occasionally retinoid dermatitis, a severe retinoid cheilitis or conjunctivitis occur, often complicated by secondary infection with S. Brelsford M, Beute TC.
Preventing and managing the side effects of isotretinoin. Semin Cutan Med Surg. Association of suicide attempts with acne and treatment with isotretinoin: Retrospective Swedish cohort study. Depression and suicidal behavior in acne patients treated with isotretinoin: A systematic review.
Low-dose isotretinoin in the treatment of acne vulgaris.
Low-dose schema of isotretinoin in acne vulgaris. Int J Clin Pharmacol Res. Medium dose isotretinoin for the treatment of acne.