Active Ingredients: Isotretinoin
Colored particles accumulated in the dermal macrophages can be observed.
Dermal macrophages can be found around the blood vessels and skin appendages 4. As we could not obtain biopsy due to cosmetic concerns, we could not provide precise information about the mechanism of hyperpigmentation caused by isotretinoin.
Retinoic acids demonstrate their activities, such as epidermal cell growth and differentiation in skin, and their activities in sebaceous glands with tissue specific receptors 6. Especially isotretinoin has receptors in human sebaceous glands and this is a precursor drug in the sebaceous glands.
It has been reported that it is activated by undergoing selective intracellular isomerization 1. The affinity of isotretinoin to pilosebaceous unit is obvious.
We did not perform histopathological examination; however, the dermoscopic examination of the lesion revealed a graycolored pigmentation change, which was especially prominent around the follicles. These findings were quite similar to the dermoscopic images that were presented in studies examining drug accumulations.
What if I forget to take it? If you take the capsules once a day and remember you've missed a dose on that day, take it as soon as you remember. If it's the next day when you remember, skip the missed dose and take the next capsule at the usual time.
If you take the capsules twice a day and forget to take a dose, take it as soon as you remember, unless this is within 2 hours of your next dose.
In this case, skip the missed dose and take the next capsule at the usual time. Never take a double dose.
Never take an extra dose to make up for a missed one. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
What if I take too much? Will the dose I take go up or down? Advice for women This medicine is likely to harm a baby.
It also increases the risk of miscarriage. If you become pregnant during treatment with isotretinoin capsules, stop taking the capsules and tell your doctor as soon as possible.
It's very important that you do not get pregnant while you're taking isotretinoin capsules. You'll be asked by your doctor to follow strict rules to prevent pregnancy during treatment and for 1 month afterwards. Read this card and the information leaflet that comes with your medicine before you start taking the capsules.
Do not breastfeed while you're using isotretinoin capsules. This medicine can get into breast milk and harm your baby.
Important Do not take isotretinoin capsules if you think you're pregnant, you know you're pregnant, or if you're breastfeeding. What if I check to take it.
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