Active Ingredients: Hydroxyzine
Use of general anaesthesia is frequently unavoidable during surgical procedures.
The ability to maintain breathing by placing a tube in the windpipe of patients undergoing general anaesthesia is therefore crucial.
A neuromuscular blocking agent NMBA is used for relaxation of muscles of the throat and is traditionally used to ease correct placement of the tube.
Objective In the present systematic review, we assessed the effect of avoiding NMBA instead of using NMBA on difficulties associated with placing a tube in the windpipe of patients undergoing general anaesthesia. Further, we evaluated the consequences of using or avoiding NMBA on events of pain or injury in the upper part of the throat following placement of a tube in the windpipe.
Study characteristics We identified 34 randomized controlled trials that met our inclusion criteria. These trials included 3565 patients who were undergoing various surgical procedures in hospital departments.
Figure 3: Positive Nikolsky sign Day 4. Close There was improvement evident at six days; on fifth day of treatment with immunoglobulin inflammatory response was limited, began reabsorption of transudate fluid of skin lesions and re-epithelialization of denuded areas.
On day nine presented improvement of oral lesions and therefore parenteral nutrition was no longer necessary.
Patient was discharged 19 days after admission in good conditions, with re-epithelialization of lesion areas, with hypopigmentation of affected areas, erosions and fragile lips but without involvement of oral cavity.
Two months after acute event there is total recovery of skin and mucous Figure 4 with hyper pigmented lesions as sequelae Figure 5. Figure 4: Two months after acute event.
Close Figure 5: Hyperpigmented lesions as sequelae. Figure 5: Hyperpigmented lesions as sequelae.
The granulysin is secreted with a perforin, which allows to enter keratinocyte and cause cell death by damage to cell and mitochondrial membrane.
The first phase acute, involves signs and nonspecific symptoms with early skin lesions. In second phase release long epidermal areas with positive Nikolsky sign.
Use of neuromuscular blocking agents NMBA to general anaesthesia is a vital procedure performed to secure a patient's airway.