Active Ingredients: Hydroxyzine
John's wort; tramadol; trazodone; and tricyclic antidepressants e. Clomipramine and imipramine have relatively high serotonergic activity compared with amitriptyline, which inhibits serotonin reuptake to a lesser degree.
In such cases, symptoms might be dismissed by clinicians or not attributed to the medication.
Many mild-to-moderate SS cases are self-limiting and usually resolve within 24 to 72 hours. This is because the fever that occurs with SS is caused by excessive muscular activity, not a change in the hypothalamic temperature set point.
The pharmacist should be knowledgeable about individual drugs and drug combinations with the propensity to cause SS TABLE 1, the mechanism of action associated with the syndrome, and common signs and symptoms of SS.
With this information, the pharmacist is better prepared to advise a patient having this reaction or to advise physicians about necessary drug changes to assure patient safety.
When a pharmacy's computer sounds an alert of a potential drug-drug interaction, the clinician should thoroughly examine the patient's medication history: What medication has the patient taken previously?
What adverse drug reactions have been previously experienced? When making drug therapy recommendations, it is essential for the pharmacist to apply knowledge of pharmacology and pharmacokinetics of causative drugs and to carry out a sound risk-benefit assessment.
Awareness of SS and education about its effects are vital. All of these factors must be considered to avoid harm to the patient.
Facts about serotonin syndrome. Am J Emerg Med.
Lerner BH. A case that shook medicine. Pharmacie Ligne Cialis.