Active Ingredients: Hydroxyzine
Cardiac safety The clinical cardiac safety of bilastine has been assessed in all of the clinical trials performed so far[ when? Interactions Preclinical data suggest the possibility of interactions between bilastine and drugs or food that are inhibitors or inducers of the P-glycoproteins.
In different murine models, bilastine by oral route, antagonizes the effects of histamine in a dose-dependent manner, with potency similar to that of cetirizine and between 5.
In vivo experimentation confirmed the antihistaminic and antiallergic activity, which was at least comparable to that of other second-generation H 1-antihistamines such as cetirizine.
Journal of Investigational Allergology and Clinical Immunology.
Similarly, bilastine was more effective in ocular symptoms relief than placebo and as effective as active comparators. Reduction of symptoms in many patients with cold urticaria requires high dosing with antihistamines, up to four times the daily recommended dose.
Krause et al. The frequency of these adverse effects in patients with SAR were comparable with that of desloratadine.Important information.
The first generation antihistamines cross the blood—brain barrier and bind the H 1-receptors on postsynaptic neurons membranes in the central nervous system, causing sedation and impaired mental status, while the second-generation antihistamines usually do not cross the blood—brain barrier and have fewer sedative effects.
Moreover, bilastine demonstrated to produce only very little or even no performance impairment. Also cardiac safety was confirmed at therapeutic and supra-therapeutic doses.
In AR treatment, its efficacy has been documented in several large controlled clinical trials. Bousquet et al. In a comparable review of the medical literature on the effectiveness of bilastine in urticarial syndromes, either spontaneous or inducible, Jauregui et al.
Differently from most antihistamines, bilastine does not increase the CNS depressant effect of lorazepam and, unlike other second-generation antihistamines such as cetirizine, does not increase alcohol effects on the CNS.
The balance of efficacy and safety of bilastine is particularly helpful when dosages higher than standard are needed to control the symptoms. References 1. World health organization.
The lowest available dose of hydroxyzine is 10 mg, which is available in the form of tablets or syrup. Histamine can cause symptoms of allergies such as sneezing, runny nose, or hives on the skin.
It is used in the treatment of itchiness, anxiety, and nausea, including that due to motion sickness.
It usually is taken three or four times a day. Vistaril is the exact same drug as Atarax simply under a different brand name. The oral tablets are available in the following strengths — Atarax 10 mg, Atarax 25 mg, Atarax 50 mg, and Atarax 100 mg.