Active Ingredients: Ciprofloxacin
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I was temporally struck at how our voi had become a such anaphylaxis of our organics. The present study was undertaken to determine whether treatment with ciprofloxacin for 3 days was as effective as treatment with ciprofloxacin for 14 days for persons with spinal cord injury who have lower urinary tract symptoms.
Methods Study design. The present study was a prospective, randomized, double-blind comparison of the therapeutic efficacy and safety of treatment with ciprofloxacin given orally for 3 days, followed by placebo given for 11 days, compared with treatment with ciprofloxacin given for 14 days.
Patients who had a pathogen known to be resistant to ciprofloxacin before therapy, who were receiving fluoroquinolone prophylaxis for the prevention of UTI, who were likely to be noncompliant regarding follow-up, or who had severe underlying illness with a high associated probability of death occurring in the near future also were not eligible for enrollment.
Written, informed consent was obtained from all study subjects.
Medication regimens. Subjects were randomized, by use of a computer-generated randomization sequence, to receive either 250 mg of ciprofloxacin orally b.
The medications were dispensed as follows: 6 tablets of ciprofloxacin were dispensed from the first bottle, and 22 tablets of either ciprofloxacin or placebo were dispensed from the second bottle.
The active-drug and placebo tablets were identical in color, taste, and odor.
The allocation code was known only to the clinical trial pharmacist. Subjects were advised to avoid taking antacids that contained magnesium or aluminum or supplements that contained iron while they were taking the study medication.
Any subjects who were taking prophylactic antimicrobials at enrollment discontinued taking them. Clinical and laboratory assessments. A standard history was obtained and a physical examination was completed at enrollment; the type and duration of symptoms were recorded.
Blood urea nitrogen and serum creatinine levels were determined if they had not been documented within the previous 6 months or if renal function was unstable.The optimal duration of treatment for symptomatic UTI has not been determined. Urinary tract infection UTI is common among patients with spinal cord injury.
Women of child-bearing potential had a pregnancy test performed, and patients receiving theophylline had the level of theophylline in blood determined.