Active Ingredients: Ciprofloxacin
If this range of antibiotics could be increased, it would be of benefit to patients, who could avoid the need for intravenous therapy, and associated costs and hospitalisations would be reduced.
An initial step in considering if the range of antibiotics could be increased is an analysis of published antibiotic pharmacological data, including a pharmacokinetic analysis. Understanding variability in antibiotic pharmacokinetics has relevant practical applications.
Alternatively, using a pharmacodynamic clinical efficacy target, patient characteristics which impact on pharmacokinetics and bacterial antibiotic susceptibility, it is possible to individualise antibiotic dosing regimens.
In addition, if geographically restricted antibiotic susceptibility is used, it is possible to make predictions about antibiotic efficacy in specific geographical locations.
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