Active Ingredients: Doxycycline
The photosensitization phototoxicity or photoallergy is usually caused by UVA radiation, because UVA penetrates deeper into the skin and most of the offending drugs absorb UV radiation in the UVA spectrum of 320—400 nm.
Following UV irradiation and photon absorption, drug molecules in an excited energy state cause chemical reactions when they return to their energetic base level, resulting in the synthesis of photoproducts that act as a haptens or antigens, generating an allergic reaction 10.
The fact that tanned skin blocks or absorbs part of the UV irradiation, or is immunologically suppressed, could explain the preliminary failure of an inflammatory skin reaction in the tanned areas of skin in our patient.
The UVB photosensitivity in our patient can be explained by her medication. Because they were well tolerated for many years, and no reaction occurred after UV sensitivity and photopatch tests under continuous drug use, it is unlikely that they are causative for the erythroderma.
The negative photopatch test with 1. Histopathological examination of the lesion with detection of a superficial perivascular lymphocytic infiltrate with variable numbers of plasma cells can be helpful, but is by far not pathognomonic.
The differential diagnosis of photoallergic vs. Phototoxic potential of minocycline and doxycycline. Arch Dermatol 1972; 105: 681—683.
Photo-onycholysis due to tetracycline hydrochloride and doxycycline. Arch Dermatol 1971; 103: 520—521.
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Photosensitivity due to doxycycline hydrochloride with an unusual flare. Contact Dermatitis 1997; 37: 93—94.
Molecular detection of Borrelia burgdorferi in formalin-fixed, paraffin-embedded lesions of Lyme disease.This group claims that your personality is result of neither nature nor. A headache is a condition of mild to severe pain in the.
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Photopatch testing: a pharmacy methodology for Europe. Cold Dermatol 1971; 103: 520-521.