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Metrics details Abstract The Lyme arthritis is a common manifestation of infection with Borrelia burgdorferi spirochete. The knee is affected Fig.
The ankle is found to be the second most commonly involved joint. Correspondingly, the clinical image can resemble a mono- or oligoarticular JIA.
Still, polyarticular involvement should not automatically exclude LA. In a study published by Tory et al.
Spirochetal factors of inflammation The B. Spirochetal antigen OspC is a factor crucial for the invasion of a host. OspC is highly immunogenic and is one of the primary inductors of host immune response.
Moreover, it interacts with plasminogen which is likely to enable spirochetal dissemination to peripheral tissues.
Through its surface molecules. As reviewed by Nardelli et al. Additionally. There is also evidence of roles for several constituents of tick saliva.
B-cell inhibitory protein and sialostatin L are also involved in local suppression of immune response. Immunological background Presence of spirochetes at synovial sites triggers development of joint inflammation Fig.
They can also eliminate spirochetes through phagocytosis. Zeidner et al.