Active Ingredients: Doxycycline
Phages have features that give them advantages over antibiotics. However, phage-resistant mutants that had lost phage receptors on the cell surface proved to be less pathogenic than phage-susceptible ones Capparelli et al.
Phages are commonly found in the biosphere and therefore are environmentally friendly, because they are natural structures based on natural selection Golkar et al.
An important aspect from the therapeutic point of view is the ability of phages to be temperate e. These factors are critical for the safety of phage therapy.
However, Modi et al.
To take advantage of the maximal phage potential, a regulatory framework should be established Jassim and Limoges,. Successful phage therapy requires phages of only proven lytic activity, whose lifecycle results from the burst size Mirzaei and Nilsson,.
As emphasized by Nilsson, phages intended to be used in phage therapy need to be well characterized, produced under appropriate conditions to obtain the required titer, validated, purified, and approved for clinical use.
This will create a chance to minimize the problem of bacterial resistance to antibiotics.
Thus, it is necessary to conduct phase III clinical trials Vandenheuvel et al. Table 1 summarizes phage topical application in the therapy of skin infections.
All the described studies Table 1 concern infections caused by bacteria other than P.
Topical phage therapy of infection. Phages Active Against Propionibacterium acnes Bacteriophages are a viral component of the skin microbiome, but the knowledge about them in this environment is scant Hannigan and Grice,, probably because of the colonization of a specific ecological niche anaerobic microenvironment.
Since 1964 it has been known that bacteriophages are one of the components of the human skin community Brzin.
In the skin microenvironment where there is a lack of bacteria other than P. The characteristics of described P. Described phages that are active against Propionibacterium acnes.
Antibiotic resistance of P. Liu et al.
It was also demonstrated that the transmission of phages between individuals is possible. Interestingly, phages active against P.Secondary posterior chamber intraocular lens PCIOL after primary tectonic surgery. Table 2 Successive optical surgical treatment implantation consisted of three surgical methods.
Furthermore, the transmission of skin phages is likely between closely related people. Marinelli et al.
The virus does not pass easily from birds to people and does not to pass from person to person except in very rare cases of close contact with an infected blood relative.
In addition, travelers are advised to: 1. Cook poultry and egg dishes thoroughly.