Active Ingredients: Doxycycline
None of the patients lost to follow-up was admitted to Parkland Hospital over the course of the study or at 1 month after study completion, by review of electronic records. While virtually all of the existing data for the efficacy of off-patent oral antimicrobials used in treating MRSA SSTI are observational or retrospective in nature, this trial begins to provide needed prospective randomized data for empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient SSTI in an area of high prevalence of MRSA.
We chose trimethoprim-sulfamethoxazole and doxycycline as they are less expensive oral antimicrobials with similar twice-daily dosing.
The occurrence of all failures in the trimethoprim-sulfamethoxazole group of empirical treatment of SSTI needs to be evaluated in a large and blinded trial.
Importantly, as it has been shown that many community-associated MRSA SSTI can be adequately managed with incision and drainage alone, without the use of antimicrobials, further investigation is also needed to better determine which SSTI require antimicrobials and which do not 5.
Acknowledgments No financial support.
Carter. Ebers. Younes, and M.
Doxycycline for community-associated methicillin-resistant Staphylococcus aureus skin and soft-tissue infections.
Jernigan. Powers. Acute MRSA Cellulitis 1 A This 19-month-old boy presented with left periorbital edema and erythema five days after having been diagnosed in an ER with conjunctivitis and treated with oral and topical antibiotics.
These studies also found that preseptal cellulitis was the most common ophthalmic MRSA presentation from to,2,3 followed by conjunctivitis, corneal ulcer, endophthalmitis, and orbital cellulitis; and the average age of patients was 32.
The answer appears to be that the CA form of MRSA is associated with a particular staphylococcal toxin known as Panton-Valentine leukocidin, which causes tissue necrosis and leukocyte destruction.
This toxin, a major factor in the etiology of abscesses of the skin and eyelids, is rarely produced by other types of S. Oral Antibiotics for Preseptal Cellulitis The following oral antibiotic regimens are appropriate choices for controlling mild to moderate CA-MRSA infections, such as preseptal cellulitis and dacryocystitis.
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