Active Ingredients: Doxycycline
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Epidemiologic studies of persistent adverse events in which information was presented regarding the adverse events occurring at least 28 days post-doxycycline-cessation are then summarized, with the emphasis on reported results of persistent adverse events associated with the use of doxycycline, including results of studies in which other antimalarial drugs were used as a comparison group.
Concurrent Adverse Events The FDA package insert for doxycycline uses information from trials that used doxycycline at dosages or for purposes other than for malaria prophylaxis e.
All labels provide a lengthy list of adverse reactions that appear to be based on postmarketing experience, but they are not quantified, nor is the type of use of doxycycline always specified.
The committee chose to use published information on concurrent adverse events from the Cochrane Database of Systematic Reviews and other reviews in which doxycycline was used for malaria prophylaxis.
The most commonly reported adverse events associated with the use of doxycycline are gastrointestinal symptoms and photosensitivity.
Studies show that nausea is more likely to occur if doxycycline is taken without food Ohrt et al. These include onycholysis, benign intracranial hypertension, skin hyper-pigmentation, postinflammatory elastolysis, tooth discoloration, vertigo, ataxia, Clostridium difficile diarrhea, visual disturbances, and phlebitis Klein and Cunha, 1995; Tan et al.