Active Ingredients: Gabapentin
Pain that persists for at least 3 months after resolution of the rash is called PHN, and in some individuals, this condition can linger for months or even years.
In the previous issue of Clinical Geriatrics, we examined the pharmacotherapies for diabetic peripheral neuropathy DPN. Thus, improving upon treatments for opioid withdrawal in particular is of great importance, not only for opioid detoxification purposes in opioid-dependent prescription opioid abusers and pain patients, but also for providing a smooth transition from opioid agonist to naltrexone maintenance.
Gabapentin is indicated for the treatment of post herpetic neuralgia and as adjunct therapy for epilepsy Pfizer. These findings indicate a relationship between gabapentin and the opioid system that is similar to that observed with L-type calcium channel blockers e.
Moreover, given that the GABA system has been implicated in the expression of withdrawal e.Published in final edited form. Exp Clin Psychopharmacol.
In addition, gabapentin has a favorable side effect profile, minimal, if any, drug interactions, and a relatively short elimination half-life of 5—9 hours Bourgeois,. The favorable side effect profile of this agent and limited drug interactions should make it a potentially good candidate for combination therapy for opioid withdrawal.
Gabapentin at low doses i. Bowsher D.
The effects of pre-emptive treatment of postherpetic neuralgia with amitriptyline: a randomized, double-blind, placebo-controlled trial. J Pain Symptom Manage. Treatment response in antidepressant-naive postherpetic neuralgia patients: double-blind, randomized trial.
Gabapentin extended-release tablets for the treatment of patients with postherpetic neuralgia: a randomized, double-blind, placebo-controlled, multicentre study. Clin Drug Investig. Efficacy and tolerability of gastric-retentive gabapentin for the treatment of postherpetic neuralgia: results of a double-blind, randomized, placebo-controlled clinical trial.
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