Active Ingredients: Gabapentin
Clark. As solvent extraction, acid-base extraction, chromatography, crystallization, distillation and the like, isolated and purified.The cells were excited with a at 350 and 385 nm.
In turn, the halogenated 1,2,4-triazole derivative prepared in Scheme 3 is reacted with a species Y under metal-catalyzed cross-coupling conditions, where E is a metallic or metalloid species, such.
The coupling can be replaced by a homogeneous catalyst, such. Typically, a base, such.
K 2 CO 3, NEt 3 and the like, in the reaction mixture. Subsequently, the reaction mixture is maintained at a suitable temperature for a time in the range of about 4 to 48 hours, with 18 hours typically being sufficient see, for example, Miyaura.
Suzuki. The Compounds of the invention can also prepared as illustrated in Scheme 4 below become.
Scheme 4 In Scheme 4 uses the same synthetic chemistry as Scheme 3, however, the functional group W is now bound to the species Y, and E is attached to the ring system X.
The disubstituted 1,2,4-triazole product from Scheme 4 can be obtained by using standard methods such. One Another method is illustrated in Scheme 5 below.
Species X can be treated with an azide group such. This reaction is often in the presence of an added catalyst, such. Boegesoe, KP; Meier. Further can the compounds of this invention according to the scheme below 6 are made: Scheme 6 The resulting 1,2,3-triazole of Scheme 5 can then be coupled with a species Y substituted with a group W.
B OR 2, BiLn and the like, the reaction can with stoichiometric or catalytic amounts of metal salts, such.
In this case, you can also additional promoters, such as 1,10-phenanthroline and dibenzylideneacetone, to the reaction mixture be added. The Products of Scheme 6, two isomeric disubstituted 1,2,3-triazoles, can by using standard methods, such.
One Another method is illustrated in Schemes 7 and 8 below.
Species Y is treated with an azide group such. Scheme 8 The resulting 1,2,3-triazole of Scheme 7 can then be coupled with a species X which is substituted with a group W Scheme 8.