Active Ingredients: Gabapentin
Results Unilateral microinjection of gabapentin into the NTS produced prominent dose-related depressor and bradycardic effects in SHR rats.
Many studies have demonstrated that gabapentin 800 mg in a single or double dose is equally effective in attenuating the hypertensive response to laryngoscopy and tracheal intubation in treated hypertensive patients.
The nucleus tractus solitarii NTS is located in the dorsal medulla of the brainstem, which is the primary integrating center for cardiovascular regulation and other autonomic functions of the central nervous system.
Our previous studies demonstrated that several neuromodulators, including adenosine, 23 angiotensin II, 24 angiotensin III, 25 carbon monoxide, 26 insulin, 27 renin, 28 neuropeptide Y, 29 nicotine 30 and nitric oxide, 31 are involved in cardiovascular control through the NTS.
Moreover, many medicines such as simvastatin 32 and resveratrol 33 improve blood pressure through their effect in the NTS. In this study, we examined the pharmacological mechanisms using microinjection of gabapentin into the NTS and observed regulatory effects on blood pressure BP and heart rate HR.
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