Active Ingredients: Norfloxacin
DOI: 10. Molecular Pharmaceutics . Andrew S. Tatton, Helen Blade, Steven P.
Brown, Paul Hodgkinson, Leslie P. Hughes, Sten O. Nilsson Lill, Jonathan R. Paluch, and Lidia Tajber.
Molecular Pharmaceutics . Hans Wolfgang Spiess.Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, in either machine-readable form or any American Chemical Society. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information.
Macromolecules . Macromolecules .
Analytical Chemistry, 88 23, 11412- Hanah Mesallati, Naila A. Mugheirbi, and Lidia Tajber.
Marta K. Chemical Reviews . Medications Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and increasing theophylline blood levels.
Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the metabolic clearance of theophylline.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine.
This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours.