Active Ingredients: Norfloxacin
Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly. Medications Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and increasing theophylline blood levels.
Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the metabolic clearance of theophylline.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine.
This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
In particular, do not take painkillers called non-steroidal anti-inflammatory drugs NSAIDs, such as ibuprofen, while you are taking norfloxacin. Some people develop thrush redness and itching in the mouth or vagina after taking a course of antibiotics.
If you think you have thrush, speak with your doctor or pharmacist for advice. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
Make sure your reactions are normal before you drive, operate machinery or do any other jobs which could be dangerous if you are not sufficiently alert. Can norfloxacin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with norfloxacin.
You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common norfloxacin side-effects What can I do if I experience this? Feeling sick nausea or being sick vomiting, indigestion, tummy abdominal pain Stick to simple foods - avoid rich or spicy meals Diarrhoea Drink plenty of water to replace lost fluids.
If the diarrhoea is severe or continues to be a problem, speak with your pharmacist or doctor for advice Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know Feeling dizzy Do not drive and do not use tools or machines until you feel well again Rash If this is severe, let your doctor know Important: there are also a number of less common but more serious side-effects which have been associated with norfloxacin.
Quality clinical trials double-blinded, randomized-controlled setting with non-fluoroquinolone antibacterial agents are urgently needed in patient populations with fluoroquinolone-resistant CBP.
In refractory or fluoroquinolone-resistant chronic bacterial prostatitis, repeated courses of treatment, or long-term antimicrobial treatment is recommended using antimicrobials to which the pathogen is susceptible, based on careful analysis of the antibiogram.
Prostate surgery is only recommended in patients with chronic bacterial prostatitis who have proven bladder outflow obstruction, with prostatitis likely complicating a concomitant condition of benign hyperplasia GoR C.
There are insufficient data on alternative and complementary medicine approaches for patients with chronic bacterial prostatitis GoR D.
Non-systemic delivery of antibacterial drugs is not recommended GoR D.