Active Ingredients: Norfloxacin
Ciprofloxacin is being licensed for the treatment of Complicated Urinary Tract Infections and Pyelonephritis due to Escherichia coli and Inhalational Anthrax post-exposure and levofloxacin was recently licensed for the treatment of Inhalational Anthrax post-exposure.
However, the Fluoroquinolones are licensed to treat lower respiratory infections in children with cystic fibrosis in the UK.
Adverse effects In general, fluoroquinolones are well tolerated, with most side-effects being mild to moderate. The overall rate of adverse events in patients treated with fluoroquinolones is roughly similar to that seen in patients treated with other antibiotic classes.
Centers for Disease Control study found patients treated with fluoroquinolones experienced adverse events severe enough to lead to an emergency department visit more frequently than those treated with cephalosporins or macrolides, but less frequently than those treated with penicillins, clindamycin, sulfonamides, or vancomycin.
Among these, tendon problems and exacerbation of the symptoms of the neurological disorder myasthenia gravis are the subject of "black box" warnings in the United States.
Younger people typically experience good recovery, but permanent disability is possible, and is more likely in older patients. Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture.
Fluoroquinoline treatment is associated with risk that is similar to or less than that associated with broad spectrum cephalosporins.
Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly.
Medications Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and increasing theophylline blood levels.
Antibiotics have also been found in the offshore water of the Bo Sea and the Yellow Sea with a concentration of ND—16.
In addition, it is also the largest river that drains into Bo Sea Bay. Pearl River is the largest river in southern China.
In addition, Pearl River is the source of drinking water for millions of people. Eight antibiotics have been detected in Pearl River surface waters. Take norfloxacin exactly as your doctor tells you to. The usual dose is one 400 mg tablet, taken twice a day.
Swallow the tablet with a drink of water. This is because your body absorbs less norfloxacin after a meal, which means the medicine is less effective.
Try to space out the doses over the day - so ideally, take a dose every 12 hours. Do not drink milk or take indigestion remedies or medicines containing iron or zinc such as multivitamin tablets during the two hours before you take norfloxacin, or during the two hours after you have taken a dose.
This is because these things interfere with the way norfloxacin is absorbed by your body, and stop it from working fully.