Active Ingredients: Norfloxacin
Centers for Disease Control study found patients treated with fluoroquinolones experienced adverse events severe enough to lead to an emergency department visit more frequently than those treated with cephalosporins or macrolides, but less frequently than those treated with penicillins, clindamycin, sulfonamides, or vancomycin.
Among these, tendon problems and exacerbation of the symptoms of the neurological disorder myasthenia gravis are the subject of "black box" warnings in the United States. Younger people typically experience good recovery, but permanent disability is possible, and is more likely in older patients.
Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture. Fluoroquinoline treatment is associated with risk that is similar to or less than that associated with broad spectrum cephalosporins.
Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly. Medications Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and increasing theophylline blood levels.
Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the metabolic clearance of theophylline.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine.
This might increase the risk of methotrexate toxic reactions. What Norfloxacin 400 mg is and what it is used for 2.
What you need to know before you take Norfloxacin 400 mg 3.
How to take Norfloxacin 400 mg 4. Possible side effects 5. How to store Norfloxacin 400 mg 6. Contents of the pack and other information 1. What Norfloxacin 400 mg is and what it is used for Norfloxacin the active ingredient contained in Norfloxacin 400 mg belongs to a group of antibiotics called quinolones which work by killing bacteria that cause infections.
This medicine is indicated for the treatment of bacterial infections of the urinary tract e.
If you experience tendon pain or signs of inflammation of the Achilles tendon stop taking your medicine and contact your doctor and rest the affected limb.
Providing you do not have a problem with your heart or kidneys, you should drink plenty of liquid whilst taking this medicine.
These crystals cannot be seen by the naked eye. Drinking plenty of liquid can help prevent this occurring. If you develop severe and persistent diarrhoea whilst you are taking your tablets or after stopping your tablets you should consult your doctor.
Other medicines and Norfloxacin 400 mg Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. You must tell your doctor if you are taking other medicines that can alter your heart rhythm: medicines that belong to the group of anti-arrhythmics e.
Multivitamins, products containing iron or zinc, antacids or sucralfate should not be taken at the same time as this medicine.
This medicine should be taken either 2 hours before or at least 4 hours after such products. Do not pass it on to others. This includes any possible side effects not listed in this leaflet.