Active Ingredients: Ivermectin
Search Menu Abstract Cutaneous larva migrans caused by the larvae of animal hookworms is the most frequent skin disease among travelers returning from tropical countries.
Complications impetigo and allergic reactions, together with the intense pruritus and the significant duration of the disease, make treatment mandatory. Freezing the leading edge of the skin track rarely works.
Cutaneous larva migrans is the most frequent skin disease among travelers returning from tropical countries. It is now easy to treat with new oral antihelmintic agents, which are both well tolerated and effective.
Cutaneous larva migrans is caused by the larvae of animal hookworms, of which Ancylostoma braziliense is the species most frequently found in humans. These hookworms generally live in the intestines of domestic pets such as dogs and cats and shed their eggs via feces to soil usually sandy areas of beaches or under houses.
Humans are infected in tropical and subtropical areas of endemicity by contact with contaminated soil.
The hookworm larva burrows through intact skin but remains confined to the upper dermis, since humans are incidental hosts. Larval migration through the skin is marked by an intensely pruritic, linear, or serpiginous track figure 1, left known as a creeping eruption.
Note that creeping eruptions occur in many other human skin diseases. Hookworm folliculitis is an uncommon form of cutaneous larva migrans, marked by pustular folliculitis of the buttocks figure 1, right.
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N Engl J Med 362: 896—905. Multi-drug resistance gene P-glycoprotein is expressed by endothelial cells at blood-brain barrier sites.
In 2 of the 3 studies involving tourists, A cutaneous serpiginous you characteristic of cutaneous larva migrans, the MDR 1 gene mutation affects function of this water.
Only 2 patients were worse cured by ivermectin.