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In addition, Artimisisin, and derivatives, enhance the anti-cancer activity of most conventional chemotherapy agents.

How can the potency and efficacy of Artemisinin be increased? Make a derivative such a artemether, artesenuate. Derivatives are modified artemisinin compounds possessing greater bio-availability and potency. Transferrin Tagged Artemisinin Another technique is to tag the Artemisin molecule with transferrin, the Iron carrier protein.

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Having the patient take an Iron supplement such as Iron bis-glycinate, Optferrin Pure Encapsulations increases the effect of the Artemisinin. This is thought to improve GI absorption.

Additional anti-cancer supplements work synergistally with artemisinin. The molecular pathways were not elucidated.

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One might anticipate a synergistic effect for this combination in killing cancer cells.

However, to my knowledge this has not yet been studied, and would be a good topic for NIH funding for future research.

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Dr Jiang see Left Image reported in the synergistic combination of Artesunate artemisinin derivative with allicin had a heightened anti-cancer effect on osteosarcoma cell lines in vitro and in vivo. Bar Chart shows apoptosis levels after treating Osteosarcoma cells in culture with Artesunate green arrow, Allicin blue arrow or combination of Artesunate and Allicin Red Arrow.

The combination significantly increased apoptosis and necrosis of the two cancer cell lines. A study by Dr Tolomeo showed the 3-Hydroxy Pterostilbene to be 50-100 times stronger than Resveratrol in killing multi-drug resistance leukemia cells.

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However, the plain pterostilbene was the least toxic to normal hematopoetic cells. pille inhibits HDAC histone deacetylase activity, allowing DNA binding of several transcription factors which increases expression of proapoptotic genes, and results in amplification of apoptotic pathways programmed cell suicide in the cancer cell, while sparing normal cells.

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