Active Ingredients: Orlistat
It has also been speculated that subjects treated with orlistat learn to titrate their dietary intake of fatty foods.
Another possibility is that some subjects did not use the medication as prescribed.
We found that energy density increased during the year of follow-up however, change in energy density was not associated with weight loss. On the other hand, the high attendance group maintained the reduction in energy density during treatment with orlistat more successfully than the low attendance group.
A reduced energy density has been associated with weight loss in two previous studies.Evidence Synthesis Many different diets have been tried to treat obesity, and weight loss occurs with all of.
The PREMIER study showed improved weight loss in subjects with the largest reduction in energy density compared to the subjects with the lowest reduction. The study by Ello-Martin et al.
We found that increased protein intake was associated with improved weight loss, in line with previous data. Dietary protein is associated with increased energy expenditure and less hunger.
However, the subjects had already lost about 3 kg of weight prior to the initiation of orlistat. This total change is in accordance with the weight reduction achieved in a sibutramine assisted weight loss program in obese males with SRBD.
In this study, favourable changes in the frequency of disordered breathing events and cardio-metabolic risk factors were shown concomitant with the loss in weight. A limitation of our study is that we did not measure the apnoea - hypo apnoea index after weight reduction.
However, most of the participants used continuous positive airway pressure for symptomatic treatment of their SRBD before weight loss was initiated.
Conclusions This study showed that treatment with orlistat for 1 year in a group-based behavioural program was associated with further weight reduction after an initial weight loss.
However, dietary energy density, and intakes of saturated fat and fatty dairy products increased.
MS performed all the dietary assessments and was responsible for data analysis, interpretation and manuscript preparation. ST was the principal investigator of the study, performed medical assessments, assisted with manuscript preparation and critically reviewed the manuscript.