Active Ingredients: Orlistat
Side effects The primary side effects of the drug are gastrointestinal-related, and include steatorrhea oily, loose stools with excessive flatus due to unabsorbed fats reaching the large intestine, fecal incontinence and frequent or urgent bowel movements.
They concluded: The incidence of acute liver injury was higher in the periods both immediately before and immediately after the start of orlistat treatment.
Long-term Despite a higher incidence of breast cancer amongst those taking orlistat in early, pooled clinical trial data—the analysis of which delayed FDA review of orlistat —a two-year study published in 1999 found similar rates between orlistat and placebo 0.
A multivitamin tablet containing vitamins A, D, K, and beta-carotene should be taken once a day, at bedtime, when using orlistat.
When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged.
Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. One profiling study undertook a chemical proteomics approach to look for new cellular targets of orlistat, including its off-targets.
In Australia, the European Union, and the United States, certain formulations of orlistat have been approved for sale without a prescription. Patent and Trademark Office.
In Austria, orlistat is available under the brand name Slimox. In Malaysia, orlistat is available under the brand name Cuvarlix and is marketed by Pharmaniaga.
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