Active Ingredients: Azithromycin
The disease progresses slowly and often shows a pattern of fluctuating skeletal muscle weakness.
The weakness can be more noticeable in the later hours of the day or after repeated movement of certain muscles, and then improves with a period of muscle rest.
MG can be classified into two main clinical forms: ocular and generalized.
Ocular MG: For these patients, muscle weakness is limited to the eyelids and extraocular muscles. Ptosis droopy eyelid and diplopia double vision are the main symptoms.
Generalized MG: Besides ocular involvement, multiple other muscle groups can also be affected, and the symptomatic presentation is usually highly variable. Myasthenia Crisis: Some patients can develop a life-threatening myasthenic crisis, characterized by acute or subacute respiratory failure due to respiratory muscle weakness.
Myasthenia Gravis Examination and Tests Your doctor will take a thorough history about the onset, duration and fluctuation of your symptoms. Particular attention will be paid to distinctive symptoms, such as droopy eyelids, double vision, difficulty of chewing or swallowing food, difficulty with breathing, etc.
During the physical examination, your doctor will evaluate your eye movements, looking for droopy eyelids, double vision, weakness of facial muscles and trouble with articulation.
Your doctor will test your muscle strength. The test itself is also considered relatively unreliable and nonspecific. Laboratory Tests Antibody Tests: It should be emphasized that, although a positive result can help to confirm the diagnosis, a negative antibody result cannot rule out MG.
Purely ocular MG patients are more likely to have seronegative MG. The test is performed by placing a recording electrode over the endplate region of a muscle and stimulating the related motor nerve.
The electrical nerve stimulation is set at a frequency rate 2 or 3 Hertz. The compound muscle action potential CMAP amplitude is then recorded from the electrodes over the muscle.
In normal muscles, there is no change in CMAP amplitude with repetitive nerve stimulation. Treatments Available for Myasthenia Gravis MG used to be a disabling disease, and at times, a fatal disorder. Nowadays, most patients are able to manage their conditions effectively with therapeutic agents.
Some achieve sustained remission. Patients will have different treatment strategies, each tailored according to the symptom classification purely ocular MG versus generalized MG, severity of the disease, age of the patient, respiratory or bulbar involvement and other variables.