Active Ingredients: Azithromycin
Both sex patients, 4-65 years diagnosed with primary antibody deficiency according to the European Society of Immunodeficiencies were selected. Demographic and pathologic data from the patients was collected.
Otoscopy, audiometry and statistical analysis was done. Results: Fifty-one patients were studied, 17 cases with hearing loss and 34 controls without hearing loss.
Conclusions: This is the first study of this type in our country, and we found a significative number of patients with hearing loss, being this of great importance for the quality of life for the patient.
We suggest the implementation of a complete audiologic evaluation at the time of diagnosis and follow-up to prevent severe complications in adults and in children long-term complications in language and learning.
Although memory B cells are key players in humoral defense and their numbers are commonly reduced in these patients.
Objective: to establish classification by phenotypes of patients with CVID and its correlation with the clinical manifestations.
Forty-four percent of patients with autoimmune hematological diseases, the most common immune thrombocytopenic purpura. Seven patients with CVID associated enteropathy. Four patients died, 2 due to massive lower gastrointestinal bleeding, 1 due to septic shock and one due to suicide.
Conclusions: The main utility of classifications, according to B cell subtypes, is to be able to find a marker, which identifies the genotype of the disease and with the prognosis.
In this study, patients with less than 0.This article has been cited by other articles in PMC and side effects.
The understanding of the prevalence, prognostic factors and pathophysiology of portal hypertension associated with liver disease in CVID is of fundamental importance for the adequate management of patients. Methods: Patients with a diagnosis of CVID according to criteria of the European Society for Immunodeficiencies were selected from the database of a tertiary hospital and divided into 3 groups: patients with portal hypertension PH, isolated splenomegaly and control group CVID without spleen- axis abnormalities.
For the diagnosis of splenomegaly and PH, abdominal ultrasound and tomography were analyzed.
Results: A total of 109 patients were analyzed: 34 patients were diagnosed with PH, 19 patients presented with isolated splenomegaly, and 56 patients showed no spleen-axis abnormalities.
There was no statistically significant difference between mean age of onset of symptoms, mean age at diagnosis, disease time and time between onset of symptoms and diagnosis, in the 3 groups analyzed.
Overall mortality in PH group was higher than in the other groups. Mutations in LRBA are associated with common variable immunodeficiency CVID, patients that suffers from hypogammaglobulinemia, B cell differentiation defects and autoimmunity, cells from LRBA deficient patients share defects on B-cell autophagy, activation, proliferation and apoptosis.
Material and methods: LRBA expression was evaluated in primary murine B cells after stimulation by flow cytometry. Functions to evaluate in this cell line are activation and proliferation, while apoptosis and autophagy will be evaluated in a pre-B cell line.
Results: LRBA expression in primary murine splenic B cells was observed to be inducible by LPS, with differential pattern across differentiation phases.
We observed that there is a significant increased in LRBA levels in mature B-cells in comparison to transitional cells and such expression is induced after LPS stimulation in murine B cells.
To study the role of LRBA in BCR signaling, we attempt to generate a mature B cell line that do not express LRBA, by now, two cell lines have been obtained using the lymphoblastoid derived from Burkitt lymphoma cell line, Raji, sequencing in this cell line indicates a missense change.
This cell line is currently under study to determine if after BCR crosslinking, defects in cell activation could be observed. Conclusions: We checked that LRBA is a inducible protein in primary murine B cells, and that expression seems to be greater in mature cells.
Its prevalence in patients with common variable immunodeficiency CVID is high, however there is little information regarding the type and location of the same; therefore the objective of this study is to know the type and location of bronchiectasis in a cohort of patients with CVID of third level of care.