Active Ingredients: Azithromycin
Eosinophilia usually occurs within eight weeks of any medicine being started, so agents started in this period should be discontinued initially. Symptoms have been reported to develop up to five years after initiation of a medicine.
It is also important to treat any renal, hepatic, pulmonary, CNS or any other complications of the eosinophilia.
Corticosteroids are often used, but there are no placebo controlled trials assessing their effectiveness and their role is not clear. Some sources suggest they have little benefit and no effect on outcomes, 56, 70 while others suggest that they produce a more rapid response.
There are reports of doses between 10? Immunosuppressive therapy, such as azathioprine, hydroxyurea and cyclophosphamide has also been recommended. Conclusion Literature on drug-induced eosinophilia is sparse and mainly consists of individual case reports.
It is often impossible to confirm whether the eosinophilia is truly drug induced because ethical and practical considerations make rechallenge unwarranted.
It is also highly probable that the syndrome is misdiagnosed and under-reported. The condition often appears to be a class effect, and the groups of drugs most commonly implicated include NSAIDs, antimalarials, anti-epileptics, some antibiotics and drugs for tuberculosis.
Of the more recently licensed drugs, both ACE inhibitors and proton pump inhibitors appear to be associated with eosinophilia.
More data are required on proton pump inhibitor-induced eosinophilia. The severity varies greatly; anticonvulsants appear to be associated with a potentially life threatening reaction.
The organs most often affected appear to be the lungs and the skin, although the CNS, kidney, gastrointestinal system, heart and musculosketetal system can also be affected.
Awareness of this potentially fatal condition needs to be raised to ensure prompt diagnosis. If eosinophilia develops, treatment usually consists of withdrawing the probable causative drug.
Corticosteroids are often used, but their role in the management of this condition is controversial.
Brito-Babapulle, consultant haematologist at the Royal Berkshire hospital, Reading. You must be registered and logged into the site to do this.
Any training, learning or development activities that you undertake for CPD can also be recorded as evidence as part of your RPS Faculty practice-based portfolio when preparing for Faculty membership. To start your RPS Faculty journey today, access the portfolio and tools at.Accumulate over interpreted vesicular nuclei suspected, luo connecting points termittent use linoleico, oleico palmitico.
Berkow R, Fletcher AJ. The Merck manual of diagnosis and therapy 16 th ed.
Rahway: Merck Research Laboratories, 1992. Applied therapeutics: the clinical use of drugs 5 th ed.
Vancouver: Applied Therapeutics Inc, 1993. Oxford textbook of medicine 3 rd ed. Oxford: Oxford University Press, 1995.