Active Ingredients: Azithromycin
More on that in this post The other appointments were to an optometrist and then an ophthalmologist. I started out seeing an optometrist in Puerto Rico for some dry eye issues, only to find out that optometrists in Puerto Rico are barred from writing prescriptions, even though all 50 US states allow it.
Until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised.
Developmental toxicity studies with azithromycin in rats, mice, and rabbits showed no drug-induced fetal malformations at doses up to 3, and 1 times, respectively, an adult human daily dose of 600 mg based on body surface area.
The estimated background risk of major birth defects and miscarriage for the indicated populations is unknown.
All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.Usage To reduce the development of available, they should be considered in selecting or modifying antibacterial therapy treat infections that are proven or susceptible bacteria.
Data Human Data Available data from published observational studies, case series, and case reports over several decades do not suggest an increased risk for major birth defects, miscarriage, or adverse maternal or fetal outcomes with azithromycin use in pregnant women.
Limitations of these data include the lack of randomization and inability to control for confounders such as underlying maternal disease and maternal use of concomitant medications.
Based on body surface area, this dose is approximately 3 rats and 2 mice times an adult human daily dose of 600 mg.
Maternal toxicity reduced food consumption and body weight gain; increased stress at parturition was observed at the higher dose.
Lactation Risk Summary Azithromycin is present in human milk see Data. There are no available data on the effects of azithromycin on milk production.
The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Zithromax and any potential adverse effects on the breastfed infant from Zithromax or from the underlying maternal condition.
Clinical Considerations Advise women to monitor the breastfed infant for diarrhea, vomiting, or rash.
Data Azithromycin breastmilk concentrations were measured in 20 women after receiving a single 2 g oral dose of azithromycin during labor. Breastmilk samples collected on days 3 and 6 postpartum as well as 2 and 4 weeks postpartum revealed the presence of azithromycin in breastmilk up to 4 weeks after dosing.
Breastmilk colostrum samples obtained between 12 and 48 hours after dosing revealed that azithromycin persisted in breastmilk up to 48 hours.
Safety data are available for 72 children 5 months to 18 years of age mean 7 years who received azithromycin for treatment of opportunistic infections. Adverse reactions were similar to those observed in the adult population, most of which involved the gastrointestinal tract.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.