Active Ingredients: Azithromycin
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PK Studies dice: 95467 When I originally commented I clicked the -Notify me when new feedback are added- checkbox and now every time a remark is added I get four emails with the same comment.
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Targeting CRTH 2 in severe asthma Prostaglandin D 2 PGD 2 can be generated by activated mast cells during allergic reactions and has been shown to be increased in the bronchoalveolar lavage fluid of severe asthmatics, particularly in association with recent asthma exacerbations and Type 2 biomarkers FeNO and blood eosinophils.
However, very few targets have been identified. In several chronic neutrophilic airway diseases, such as exacerbation-prone COPD, non-cystic fibrosis bronchiectasis, and bronchiolitis, treatment with low-dose macrolides, such as azithromycin and erythromycin, decreases exacerbations.
However, all the studies of these agents were performed before ICSs and LABAs became a mainstream treatment for asthma, and before any concept of phenotyping.
Therefore, their applicability today remains unclear. Further studies are clearly needed. With recent studies suggesting that asthma is a heterogeneous disease of different phenotypes and responses to selected therapies, studies which incorporate the interaction between various biomarkers and responses to specific treatments in severe asthmatics should increases.
By identifying the distinct immunologic mechanisms involved in severe, poorly controlled asthma, new targeted therapies could improve patient quality of life and our understanding of human asthma.
While several monoclonal antibodies show promise in asthma with evidence for Type 2 inflammation, further work is needed for severe asthmatics who do not show evidence of Type 2 inflammation.
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